Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2021-12-24 |
タイトル |
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タイトル |
In vitro antiproliferative and antioxidant activity of three fungal strains from the White sea |
タイトル |
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言語 |
en |
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タイトル |
In vitro antiproliferative and antioxidant activity of three fungal strains from the White sea |
言語 |
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言語 |
eng |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Antiproliferative activity |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Antioxidant capacity |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Polar marine fungi |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
著者 |
Couttolenc, Alan
Padrón, José M.
Shnyreva, Alla V.
Sergeeva, Albina I.
Kurakov, Alexander V.
Trigos, Ángel
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抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Fungi have been recognized as a prolific source of bioactive compounds with a wide spectrum of bioactivities, nevertheless, the information about marine polar fungi is scarce. Due to this fact, the purpose of this study was to investigate the antiproliferative activity and antioxidant capacity of the extracts of three fungal strains isolated from the White Sea (Coprinellus diseminatus, Simplicillium lamellicola and Akanthomyces muscarius). The antiproliferative activity test was carried out by the SRB method and the cell lines tested were A549, HBL-100, HeLa, SW1573, T-47D and WiDr. The antioxidant capacity was measured employing the ABTS and galvinoxyl methods. The strain that showed the most antiproliferative activity was A. muscarius; it demonstrated activity in all the extracts tested, at least against two of the six tested cell lines, also the biomass ethanolic extract and the culture broth ethyl acetate extract of Coprinellus diseminatus showed antiproliferative activity against some of the tested cell lines. In the antioxidant capacity test, the ethyl acetate extracts of the culture broth of the three strains showed more activity. This indicates that arctic marine-derived fungi are capable to produce bioactive metabolites with antiproliferative activity and antioxidant capacity, comparable to other marine-derived fungi, and in some cases even more active than known medicinal mushrooms. |
書誌情報 |
en : Polar Science
巻 29,
p. 100724,
発行日 2021-09
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ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
18739652 |
DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.polar.2021.100724 |
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関連名称 |
10.1016/j.polar.2021.100724 |